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KMID : 0369919950100010025
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Journal of Pharmaceutical Sciences (C.B.N.)
1995 Volume.10 No. 1 p.25 ~ p.36
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Dopaminergic Involvement in the Inhibition by Ginseng Total Saponin of Cocaine and Methamphetamine Induced Psychological Dependence
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김학성
이명구/오기완/성연희/조대현/강석연/최강주/김석창/신화섭
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Abstract
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Abstract:
@EN Drugs-induced psychological dependence was evaluated by assessing the difference in time spent in the drug-paired compartment and the saline-paired compartment of the place conidtioning apparatus. The injection of ginseng total saponin (GTS,
50
and
100 mg/kg, i.p.), prior to and during drugs treatment in mice inhibited cocaine-and methamphetamine-induced conditioned place preference. A single administration of GTS inhibited the apomorphine (2mg/kg)-induced climbing behavior while did no
block
the
N-methyl-D-aspartate(NMDA)-induce convulsion, suggesting that GTS inhibits apomorphine-induced dopaminergic activity at the postsynaptic dopamine(DA) receptor. On the other hand, cocaine and methamphetamine increase the tyrosine hydroxylase(TH)
activity
in cultured PC12 cell line. However, a single treatment with GTS inhibits TH activity. These results suggest that blockade by GTS of cocaine-and methamphetamine-induced psychological dependence is involved in inhibition by GTS of both pre and
postsynaptic receptors at DA neurons but not NMDA neurons in the central nervous system.
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KEYWORD
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